产品货号：
Z30910
中文名称：
KSHV/ORF57抗体
英文名称：
Anti-KSHV/ORF57 Antibody
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-KSHV/ORF57 Antibody |
| 指标别名 | KSHV ORF57,MTA,human herpesvirus 8 protein |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | ELISA,WB |
| 基因名称 | ORF57 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the C-terminal of human KSHV ORF57 protein. |
| 计算分子量 | 51kDa |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | This affinity purified antibody is directed against human herpesvirus 8 (KSHV ORF57) protein.The product was affinity purified from monospecific antiserum by immunoaffinity chromatography.A BLAST analysis was used to suggest cross-reactivity with ORF57 protein from human herpesvirus 8 types P and M sources based on 94% homology with the immunizing sequence.Reactivity against homologues from other sources is unknown. |
| 浓度 | 1.55mg/mL by UV absorbance at 280nm |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | This antibody is suitable for Cancer,Immunology and Nuclear Signaling research.ORF57 (also known as MTA),one of the earliest Kaposi's sarcoma-associated herpesvirus (KSHV) regulatory proteins to be expressed,is essential for virus lytic replication.A counterpart is present in every herpesvirus sequenced,indicating the importance of this signature viral protein,and those examined act post-transcriptionally,affecting RNA splicing and transport.KSHV ORF57 is capable of establishing both lytic and latent replication cycles.?In KS,the virus localizes to tumor progenitor endothelial cells,most of which are latently infected.In cell culture,KSHV replication is generally studied using B-cell lines,such as BCBL-1,generated from primary effusion lymphoma material.Most BCBL-1 cells are latently infected,although there is some spontaneous virus reactivation.Addition of chemical inducers such as sodium n-butyrate,12-O-tetradecanoylphorbol-13-acetate (TPA),and valproic acid (VA) to these cells efficiently induces the lytic cycle and produces virions.KSHV ORF57 protein predominantly localizes to the nucleus and can shuttle between the nucleus and cytoplasm.Most HSV-1 genes are unspliced;by contrast,ORF57 is spliced gene;the protein is 455 amino acids in length and 50kDa in size. |
| Uniprot ID | Q2HR75 |
| 基因名全称 | mRNA export factor ICP27 homolog |
| 推荐稀释比 | ELISA:1:100,000 - 170,000 IHC:User Optimized WB:1:5,000 - 1:8,000 |
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